How does carboprost work to stop bleeding?

Oxytocic medications have the effects of oxytocin, which causes contractions during labor and controls bleeding after childbirth. Carboprost works on prostaglandin F receptor sites in uterine muscle to increase contractions and induce labor. It is used to terminate pregnancies and control uterine bleeding.

What type of drug is carboprost?

Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions. Carboprost is used to treat severe bleeding after childbirth (postpartum).

What is the brand name for carboprost?


Hemabate intramuscular – 250 mcg/mL solution
Hemabate intramuscular – 250 mcg/mL solution

What is carboprost tromethamine used for?

Hemabate (carboprost tromethamine) Sterile Solution is a form of prostaglandin (a hormone-like substance that occurs naturally in the body) used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions.

Does carboprost cause diarrhea?

The most frequent adverse reactions observed are related to its contractile effect on smooth muscle. In patients studied, approximately two-thirds experienced vomiting and diarrhea, approximately one-third had nausea, one-eighth had a temperature increase greater than 2° F, and one-fourteenth experienced flushing.

What is Carboprost tromethamine used for?

How do you administer Carboprost tromethamine?

An initial dose of 1 mL of HEMABATE Sterile Solution (containing the equivalent of 250 micrograms of carboprost) is to be administered deep in the muscle with a tuberculin syringe. Subsequent doses of 250 micrograms should be administered at 1½ to 3½ hour intervals depending on uterine response.

Is carboprost safe for pregnancy?

Carboprost is used to treat severe bleeding after childbirth (postpartum). Carboprost is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons.

How does Carboprost tromethamine work?

Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus).

Does carboprost need to be refrigerated?

Each mL of HEMABATE contains carboprost tromethamine equivalent to 250 mcg of carboprost. HEMABATE must be refrigerated at 2° to 8° C (36° to 46° F).

What is prostin used for?

This medication is used to cause an abortion during weeks 12-20 of pregnancy. It is also used up to week 28 of pregnancy to help vaginally remove any remaining material in the womb from a miscarriage/missed abortion.

How do you administer carboprost tromethamine?

It is used to end a pregnancy. It is used to stop or treat bleeding that happens after a birth or an abortion . It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Carboprost Tromethamine?

What are the side effects of carboprost tromethamine?

Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight. What are some other side effects of Carboprost Tromethamine? All drugs may cause side effects. However, many people have no side effects or only have minor side effects.

Should I talk to my doctor about my carboprost tromethamine allergy?

If you are allergic to carboprost tromethamine; any part of carboprost tromethamine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have pelvic inflammatory disease .

How does carboprost tromethamine affect the gravid uterus?

Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. Whether or not these contractions result from a direct effect of carboprost on the myome-trium has not been determined.