How long does Zofran take to work through IV?
A 4 mg intravenous infusion of ondansetron given over 5 minutes results in peak plasma concentrations of about 65 ng/ml. Following intramuscular administration of ondansetron, peak plasma concentrations of about 25 ng/ml are attained within 10 minutes of injection.
How long does Zofran take to metabolize?
Following oral or IV administration, ondansetron is extensively metabolised and excreted in the urine and faeces 9,10. The half-life of ondansetron after either an 8 mg oral dose or intravenous dose was approximately 3-4 hours and could be extended to 6-8 hours in the elderly 9,10.
What is the onset peak and duration of ondansetron?
Since the time to reach peak concentration is 0.5 to 2 hours after oral ingestion, the drug should be administered at least 30 minutes before chemotherapy. Possible alternative ways of administration of ondansetron include intramuscular, subcutaneous and rectal administration, and oral controlled-release formulations.
How long does Zofran IV last in your system?
Zofran (ondansetron) should work pretty quickly. Many people report relief within about 30 minutes and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran (ondansetron) can last anywhere between 8 to 12 hours.
Why is Zofran given slowly?
Do not give this medication any faster than recommended or take more than the recommended dose because this may increase the chance of serious side effects such as blurred vision or slowed/irregular heartbeat.
How long does it take for ondansetron to start working?
Ondansetron should start to work within 30 minutes to an hour. Ondansetron tablets are available in two different forms – tablets or oral disintegrating tablets (also called ODT). Tablets: swallow the tablets with a glass of water. Do not halve or crush the tablets.
How long does sublingual Zofran take to work?
Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran’s effects can last 8 to 12 hours. The Zofran dosage varies depending on the severity and cause of the nausea and vomiting.
What is the onset of Zofran?
The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. Subsequent doses (0.15 mg/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of ZOFRAN.
How do you give Zofran IV push?
In paediatric clinical studies, ondansetron was given by IV infusion diluted in 25 to 50 ml of saline or other compatible infusion fluid (see Instructions for Use and Handling) and infused over not less than 15 minutes. Ondansetron should be administered immediately before chemotherapy as a single IV dose of 5 mg/m2.
How long does a shot of Phenergan last?
Clinical effects are generally apparent within 5 minutes of an intravenous injection and within 20 minutes of an intramuscular injection. Duration of action is four to six hours, although effects may persist up to 12 hours.
What happens if you take Zofran too soon?
An overdose of Zofran can be a serious medical emergency or even fatal, so get emergency medical attention if too much Zofran has been taken. A Zofran overdose will cause symptoms such as temporary vision loss, severe constipation, light-headedness, and fainting.
How is IV Zofran administered?
Doses up to 4 mg may be administered undiluted (2 mg/mL) over at least 30 seconds and preferably over a period of 2 to 5 minutes. For doses more than 4 mg and for chemotherapy-induced nausea and vomiting (CINV), dilute ondansetron in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection.