Is vimentin a mesenchymal marker?

In recent years, vimentin has been recognized as a marker for epithelial-mesenchymal transition (EMT). Although EMT is associated with several tumorigenic events, vimentin’s role in the underlying events mediating these processes remains unknown.

What is vimentin positive?

In conclusion, vimentin-positive gastric cancer was associated with the highly invasive phenotype of advanced gastric cancer, especially with scirrhous type of gastric carcinoma. Vimentin may play an important role in the metastasis of gastric carcinoma.

Does vimentin positive mean cancer?

Background/aim: Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro.

What is vimentin in cancer?

Vimentin (VIM) is a type III intermediate filament that maintains cell integrity, and is involved in cell migration, motility and adhesion. When overexpressed in solid cancers, vimentin drives epithelial to mesenchymal transition (EMT) and ultimately, metastasis.

Is vimentin a marker of EMT?

Vimentin is one type of EMT protein marker, which is present in mesenchymal cells and involved in cancer progression [4, 7, 11, 15].

What is vimentin expression?

Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas.

Is vimentin positive in melanoma?

The data showed that high expression of vimentin was significantly associated with melanoma hematogenous metastasis.

What cells express vimentin?

Vimentin is a widely expressed and highly conserved 57-kD protein that is constitutively expressed in mesenchymal cells, including endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes (3–8).

What is mesenchymal tumor?

Mesenchymal tissue neoplasms are soft tissue tumors, also known as connective tissue tumors, which are relatively frequent in domestic animals and have a high incidence in some species. These tumors may be located in all organs, with a higher or lower incidence in some tissues, as it will be shown.

Is vimentin expressed in epithelial cells?

In vivo, vimentin is not usually present in normal epithelial cells; however, it has been cultured in vitro in epithelial cells and may also show expression in tumor cells of epithelial origin, usually in paraffin tissue following antigen retrieval.

Is vimentin expressed in neurons?

Vimentin (Vm) is initially expressed by nearly all neuronal precursors in vivo, and is replaced by neurofilaments (NFs) shortly after the immature neurons become post-mitotic. Both Vm and NFs can be transiently detected within the same neurite, and Vm is essential for neuritogenesis at least in culture.