What does it mean to have a positive HBeAb?
Those with a positive HBeAg have active replication in their liver cells, more of the virus circulating in their blood, and as a result, they are more infectious, with a higher likelihood of transmitting HBV to others. Most often, when a person is HBeAg positive, they tend to be HBeAb negative and vice-versa.
Is HBeAg negative good?
Generally, doctors recommend treatment to HBeAg-negative patients when their viral load exceeds 2,000 IU/ML and their ALT liver enzyme levels, which rise when liver cells are damaged, are even moderately elevated.
What if HBsAg is positive and HBeAg-negative?
If this HBsAg-positive, HBeAg-negative patient’s HBV DNA titer is currently ≥ 100,000 copies per mL in the presence of normal aminotransferases, the patient should undergo liver biopsy. If there is significant hepatic necroinflammatory disease and/or fibrosis found on biopsy, the patient will be eligible for treatment.
What is the normal range of HBeAg?
Laboratory tests The dynamic range of HBsAg levels was 0.05-250 IU/mL.
Can HBsAg positive become negative?
As many as 20 to 30% of these acute exacerbations may be caused by superinfection with HDV, HCV, or hepatitis A virus and can be associated with an increased risk of fulminant hepatic failure . Some carriers eventually become HBsAg negative and develop anti-HBs.
Can hepatitis B positive change negative?
After years of living with “inactive’ chronic hepatitis B—with low viral load and no signs of liver damage–some patients may finally lose the hepatitis B surface antigen (HBsAg) and even develop surface antibodies.
What HBeAg reactive?
REACTIVE: A REACTIVE HBeAg indicates rapid viral replication usually associated with high HBV DNA levels. HBeAg-REACTIVE patients are considered highly infectious.
What is HBsAg negative mean?
Normal results are negative or nonreactive, meaning that no hepatitis B surface antigen was found. If your test is positive or reactive, it may mean you are actively infected with HBV. In most cases this means that you will recover within 6 months.
Can HBsAg positive become negative after treatment?
Although HBsAg levels remain unchanged during lamivudine (LMV) treatment, recent studies report an association between a reduction of serum HBsAg level and viral suppression after entecavir (ETV) treatment.