What is CD58 a marker for?

CD58 (leucocyte function-associated antigen 3; LFA-3) is a useful marker in MRD tracking of B cell precursor (BCP) ALL. CD58 is over expressed in these cases permitting discrimination of leukaemia blasts from normal B cells.

Do t cells express CD58?

DCs costimulate CD28− T cells via CD58/CD2 DCs are generally regarded as the primary APCs. We assessed the expression and regulation of costimulatory ligands on monocyte-derived DCs. We found that in addition to CD80 and CD86, these cells also express CD58 and CD166.

What does LFA 3 bind to?

protein CD2
LFA 3 (identified by the monoclonal antibody CD58) is a widely expressed cell surface protein whose only known function is to act as the binding ligand for the T-cell surface protein CD2.

What the term LFA 3 mean and what its function?

Lymphocyte function-associated antigen 3 (LFA-3) is a widely distributed cell surface glycoprotein that binds to the T lymphocyte CD2 surface glycoprotein. This interaction mediates CTL-target cell conjugate formation and adhesion of thymocytes to thymic epithelial cells.

Do all T cells have cd3?

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains….CD3 (immunology)

CD3d molecule, delta
Alt. symbols T3D
NCBI gene 915
HGNC 1673

Where is CD40 expressed?

CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. It can also be expressed by endothelial cells, smooth muscle cells, fibroblasts and epithelial cells.

Is CD4 T-cell receptor?

CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule.

What is anti CD2?

Anti-CD2 treatment provides targeted immunomodulatory properties that have demonstrated clinical usefulness to condition the immune system and to treat transplant rejection. The treatment is species-specific due to structural CD2 antigen differences between nonhuman primates and humans.

What are CD3 molecules?

Cluster of differentiation 3 (CD3) is a multimeric protein complex, known historically as the T3 complex, and is composed of four distinct polypeptide chains; epsilon (ε), gamma (γ), delta (δ) and zeta (ζ), that assemble and function as three pairs of dimers (εγ, εδ, ζζ).

Is CD3 an antigen?

The CD3 antigen is a surface structure associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction.

What is CD40 signaling?

CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death.

What is CD40 on B cells?

CD40 is a member of the tumor necrosis factor receptor (TNF) superfamily and is broadly expressed by immune and other normal cells [9]. CD40 itself lacks intrinsic signal-transduction activity and mediates its effects via downstream adapter molecules that regulate gene expression.

What does CD58 stand for?

The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells.

What is the role of Cd2 and CD58 in T cells?

The anti-CD2 and anti-CD58 mAbs induce T cell unresponsiveness to mitogenic or antigenic stimuli and inhibit CTL-mediated killing by binding to the T cells and target cells, respectively (111). These results reveal the critical role of the CD2-CD58 interaction in T cell stimulation.

What forms of CD58 are released from the cell surface?

Itzhaky D, Raz N, Hollander N. The Glycosylphosphatidylinositol-Anchored Form and the Transmembrane Form of CD58 are Released From the Cell Surface Upon Antibody Binding. Cell Immunol(1998) 187(2):151–7.

Is CD58 a stem cell marker or oncogene?

In addition to mediating T immune response in solid tumors, several recent reports have demonstrated that CD58 molecule can serve as stem cell marker or an oncogene in tumor initiation and progression.