What is CD58 a marker for?
CD58 (leucocyte function-associated antigen 3; LFA-3) is a useful marker in MRD tracking of B cell precursor (BCP) ALL. CD58 is over expressed in these cases permitting discrimination of leukaemia blasts from normal B cells.
Do t cells express CD58?
DCs costimulate CD28− T cells via CD58/CD2 DCs are generally regarded as the primary APCs. We assessed the expression and regulation of costimulatory ligands on monocyte-derived DCs. We found that in addition to CD80 and CD86, these cells also express CD58 and CD166.
What does LFA 3 bind to?
LFA 3 (identified by the monoclonal antibody CD58) is a widely expressed cell surface protein whose only known function is to act as the binding ligand for the T-cell surface protein CD2.
What the term LFA 3 mean and what its function?
Lymphocyte function-associated antigen 3 (LFA-3) is a widely distributed cell surface glycoprotein that binds to the T lymphocyte CD2 surface glycoprotein. This interaction mediates CTL-target cell conjugate formation and adhesion of thymocytes to thymic epithelial cells.
Do all T cells have cd3?
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains….CD3 (immunology)
|CD3d molecule, delta|
Where is CD40 expressed?
CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. It can also be expressed by endothelial cells, smooth muscle cells, fibroblasts and epithelial cells.
Is CD4 T-cell receptor?
CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule.
What is anti CD2?
Anti-CD2 treatment provides targeted immunomodulatory properties that have demonstrated clinical usefulness to condition the immune system and to treat transplant rejection. The treatment is species-specific due to structural CD2 antigen differences between nonhuman primates and humans.
What are CD3 molecules?
Cluster of differentiation 3 (CD3) is a multimeric protein complex, known historically as the T3 complex, and is composed of four distinct polypeptide chains; epsilon (ε), gamma (γ), delta (δ) and zeta (ζ), that assemble and function as three pairs of dimers (εγ, εδ, ζζ).
Is CD3 an antigen?
The CD3 antigen is a surface structure associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction.
What is CD40 signaling?
CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death.
What is CD40 on B cells?
CD40 is a member of the tumor necrosis factor receptor (TNF) superfamily and is broadly expressed by immune and other normal cells . CD40 itself lacks intrinsic signal-transduction activity and mediates its effects via downstream adapter molecules that regulate gene expression.
What does CD58 stand for?
The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells.
What is the role of Cd2 and CD58 in T cells?
The anti-CD2 and anti-CD58 mAbs induce T cell unresponsiveness to mitogenic or antigenic stimuli and inhibit CTL-mediated killing by binding to the T cells and target cells, respectively (111). These results reveal the critical role of the CD2-CD58 interaction in T cell stimulation.
What forms of CD58 are released from the cell surface?
Itzhaky D, Raz N, Hollander N. The Glycosylphosphatidylinositol-Anchored Form and the Transmembrane Form of CD58 are Released From the Cell Surface Upon Antibody Binding. Cell Immunol(1998) 187(2):151–7.
Is CD58 a stem cell marker or oncogene?
In addition to mediating T immune response in solid tumors, several recent reports have demonstrated that CD58 molecule can serve as stem cell marker or an oncogene in tumor initiation and progression.