What is genotype 1a HCV?

Background. Hepatitis C virus (HCV) genotype 1 is the most prevalent worldwide. Subtype 1a, compared with 1b, shows lower response rates and higher propensity to select for drug resistance to NS3 and selected NS5A and nonnucleoside NS5B inhibitors. Two distinct clades of subtype 1a have been described.

Is HCV genotype 1a curable?

One of these drugs is sofosbuvir. With PEG/ribavirin treatment alone, genotype 1 HCV used to require the longest duration of treatment with the least likelihood of success. With sofosbuvir, genotype 1 is now curable in more than 95 percent of people treated for only 12 weeks.

What is HCV semi quantitative?

The viral load of hepatitis C refers to the amount of virus present in the bloodstream. The quantitative HCV RNA tests measure the amount of hepatitis C virus in the blood. The result will be an exact number, such as “1,215,422 IU/L.” Many people refer to the quantitative measurement as the hepatitis C “viral load.”

What is HCV normal range?

Normal range for this assay is “Not Detected”. The quantitative range of this assay is 10 – 100,000,000 IU/mL (1.0 – 8.0 log IU/mL).

What is a positive HCV RNA result?

If a qualitative RNA test is positive (detected), then it is confirmed that the patient has chronic hepatitis C. The “qualitative” test is more accurate than the “quantitative” test because qualitative tests are able to detect very low levels of the virus.

What is HCV test positive?

What does a reactive HCV antibody test result mean? ► A reactive or positive antibody test means you have been infected with the hepatitis C virus at some point in time. ► Once people have been infected, they will always have antibodies in their blood.

How do you read HCV results?

A positive result means that a person has the hepatitis C virus. A negative result means that the body has cleared the virus without treatment. The second test is the hep C RNA quantitative test. The result of this test is given as a number rather than a positive or negative.

What is the purpose of the HCV GT1a NS5A profile?

The HCV GT1a NS5A profile is intended for baseline determination of HCV viral load, HCV genotype, and HCV NS5A drug resistance in patients with documented HCV infection and HCV genotype 1a.

What is the NS5A resistance test for hepatitis C virus (HCV)?

Pretreatment NS5A resistance testing is recommended for all patients with HCV genotype 1a in whom elbasvir-grazoprevir is being considered to detect the presence of NS5A resistance-associated substitutions at the amino acid positions 28, 30, 31, or 93, which are associated with inferior treatment response.

What is an HCV antibody test?

The HCV antibody test, sometimes called the anti-HCV test, looks for antibodies to the hepatitis C virus in blood. Antibodies are chemicals released into the bloodstream when someone gets infected.

How conserved is HCV GT1a and GT1b?

Conversely, 60.8 per cent and 23.5 per cent were defined as, respectively, conserved and highly conserved within HCV GT1a, in comparison to 15.9 per cent and 68.5 per cent within HCV GT1b. At the nucleotide level, a higher proportion of weakly conserved positions was observed (26.4% for HCV GT1a and 29.0% for GT1b).