What is the ERK gene?

MyGenes for gene MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

What is MAPK gene?

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).

What does ERK protein stand for?

extracellular-signal-regulated kinase
The extracellular-signal-regulated kinase (ERK) pathway is one of the major signaling cassettes of the mitogen activated protein kinase (MAPK) signaling pathway.

Does MEK activate ERK?

The RAF kinase phosphorylates and activates a MAPK/ERK Kinase (MEK1 or MEK2). The MEK phosphorylates and activates a mitogen-activated protein kinase (MAPK). RAF and MAPK/ERK are both serine/threonine-specific protein kinases.

What does the active form of ERK do?

Downstream, activated ERK regulates growth factor-responsive targets in the cytosol and also translocates to the nucleus where it phosphorylates a number of transcription factors regulating gene expression (Figure 3).

What happens when MAPK is activated?

MAPKKK activation leads to the phosphorylation and activation of a MAPKK, which then stimulates MAPK activity through dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop of the kinase domain subdomain VIII (Fig. ​ 1).

What is the role of ERK?

ERK cascade plays a crucial role in multiple cellular processes such as cell proliferation, differentiation, adhesion, migration and survival. Therefore, it is essential for many physiological events including development, immunity, metabolism, and memory formation.

What is ERK Signalling?

ERK signalling in cell proliferation. In proliferating cells, RAS-induced ERK signalling primarily controls the G1/S-phase transition of the cell cycle. Notably, deletion of the three Ras genes or loss of Erk1 and Erk2 in mouse embryonic fibroblasts (MEFs) induces a cell cycle arrest in G1 phase (refs43,44).

What transcription factors does ERK activate?

ERKs can directly phosphorylate a set of transcription factors including Ets-1, c-Jun and c-Myc. ERK can also phosphorylate and activate RSK, which then leads to the activation of the transcription factor CREB.

What is the MAPK1 gene?

MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include Chromosome 22Q11.2 Deletion Syndrome, Distal and Retrograde Amnesia. Among its related pathways are Glioma and Beta-Adrenergic Signaling.

What does the gene AKT1 stand for?

GeneCards Summary for AKT1 Gene. AKT1 (AKT Serine/Threonine Kinase 1) is a Protein Coding gene. Diseases associated with AKT1 include Proteus Syndrome and Cowden Syndrome 6. Among its related pathways are Gastric cancer and Deactivation of the beta-catenin transactivating complex.

What is the string number for ATP1A1?

STRING: ENSP00000476535 ATP1A1 ENSP0000044530619 P05023122 STRING: ENSP00000445306 IID: # pred=2 ATP1B1 ENSP0000035679019 P05026122 STRING: ENSP00000356790

What are the other protein references for ANPEP gene?

Other Protein References for ANPEP Gene ENSEMBL proteins: ENSP00000502886 ENSP00000300060 ENSP00000453413 ENSP00000452934 ENSP00000453545 ENSP00000453405 P15144.228 REFSEQ proteins: