What do SH2 domains bind to?
Abstract. Src homology 2 (SH2) domains are protein modules (of approximately 100 amino acids) found in many proteins involved in tyrosine kinase signalling cascades. Their function is to bind tyrosine-phosphorylated sequences in specific protein targets.
What proteins have SH2 domains?
Proteins containing SH2 domains include those that function as kinases, adaptors, phosphatases, ubiquitin ligases, transcription factors, guanine nucleotide exchange factors and phospholipid-based secondary signaling molecules [5, 12, 30].
What do proteins with SH3 domains bind to?
The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome….
| SH3 domain | |
|---|---|
| CDD | cd00174 |
| showAvailable protein structures: |
What is the role for SH2 domains in signaling via receptor tyrosine kinases?
SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites.
What determines the specificity of SH2 interactions with other molecules?
The target specificity of individual SH2 domains is based on the recognition of the three amino acids carboxyl terminal to the phospho-tyrosine within the target molecule.
Which of the following is specifically bound by Src homology 2 domain?
tyrosine-phosphorylated peptides
Abstract. Src homology 2 (SH2) domains are evolutionary conserved small protein modules that bind specifically to tyrosine-phosphorylated peptides.
Where is SH2 domain found?
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins.
What is the role of adaptor proteins?
Adaptor proteins contain a series of protein-binding sites that link respective interaction partners to each other and facilitate the generation of larger signaling complexes (1). This is, for example, pivotal for the delivery of signals from the T cell receptor (TCR) which plays a critical role in T cell biology (2).
What is SH2 and SH3 domains?
SH2 domains bind to short phosphotyrosine-containing sequences in growth factor receptors and other phosphoproteins. SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids.
What does SH3 domain do?
The SH3 domain of Src-family PTKs, which regulate many cellular functions, such as cell proliferation and differentiation, survival, migration and cytoskeletal modifications, is mainly involved in substrate recognition and downregulation of the kinase activity.
Does casein have a SH2 domain?
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins….SH2 domain.
| Identifiers | |
|---|---|
| Pfam | PF00017 |
| InterPro | IPR000980 |
| SMART | SH2 |
| PROSITE | PDOC50001 |
What determines the specificity of the interactions of SH2 proteins with phosphorylated tyrosine residues in proteins?
For example, the binding of SH2 domains to target proteins involves the recognition of a phosphorylated tyrosine residue, and specificity of individual SH2 domains is mediated by the recognition of amino acid residues immediately C-terminal to the phospho-tyrosine (2).