What is tacrolimus in lab results?
The tacrolimus test is used to measure the amount of the drug in the blood to determine whether the concentration has reached a therapeutic level and is below the toxic level.
When should Prograf levels be checked?
For cyclosporine or tacrolimus trough-level monitoring, blood should be drawn 12 h after the last dose (i.e., immediately before the next dose).
What is a normal Prograf level?
The general therapeutic range for tacrolimus is 5-20 ng/mL.
What is a Prograf test?
This test measures the amount of tacrolimus in the blood. Tacrolimus is an immunosuppressive drug that is given orally or intravenously to patients who have had a kidney, liver, heart, or other organ transplant. It is a powerful drug that helps to prevent rejection of the transplanted organ by the body.
What makes tacrolimus level high?
Abstract. The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations.
What is tacrolimus trough level?
Generally, the tacrolimus trough level maintained between 5.35 and 7.15 ng/mL may be optimal during the first month after living relative kidney transplantation among the Chinese.
What is a toxic tacrolimus level?
The highest recorded plasma and whole-blood tacrolimus levels during the toxic episodes were respectively 2.7±0.8 ng/ml (range 1.1–3.5) and 31.6±10.6 ng/ml (range 14.5–50.5). The drug levels were considered to be beyond the therapeutic range in 18/22 (82%) patients.
What is a normal tacrolimus level after kidney transplant?
The Kidney Disease: Improving Global Outcomes guidelines suggest that 5–15 ng/mL of TAC trough levels should be maintained during the first 2–4 months post-transplant and then reduced in stable KTRs to minimize toxicity, with a low quality of evidence .
What is a toxic level of tacrolimus?
The highest mean plasma and whole-blood tacrolimus levels during the toxic episodes were 2.7 ± 0.8 ng/ml (range 1.1–3.5) and 31.6 ± 10.6 ng/ml (range 14.5–50.5), respectively. The drug levels were considered to be beyond the therapeutic range in 18/22 (82%) patients.
What happens if Prograf level is too high?
high potassium level–nausea, weakness, chest pain, irregular heartbeats, loss of movement; kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath; low magnesium or phosphate–bone pain, jerky muscle movements, muscle weakness or limp feeling, slow reflexes; or.
What is the ideal tacrolimus level?
Most individuals display optimal response to tacrolimus with trough whole blood levels of 5.0 to 15.0 ng/mL.
What are the symptoms of too much tacrolimus?
This medicine may cause serious brain or nerve problems (eg, posterior reversible encephalopathy syndrome). Tell your doctor right away if you have blurred vision, confusion, dizziness, headache, mental changes, seizures, high blood pressure, unusual drowsiness, tiredness, or weakness, or a fast heartbeat.
How do I get more information about Prograf?
The Patient Information leaflet summarizes the most important information about PROGRAF. If you would like more information, talk to your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
What is the optimal dose of Prograf for optimal response?
Clinical studies have shown that patients administered 0.07 mg/kg Prograf® obtain an optimal response to the drug at the following trough levels: 1 • Trough (immediately following transplant): 15.0 ng/mL 2 • Trough (steady-state, two weeks or more after transplant): 3.0−8.0 ng/mL More
What are the neurotoxic effects of Prograf?
Prograf may cause a spectrum of neurotoxicities. The most severe neurotoxicities include posterior reversible encephalopathy syndrome (PRES), delirium, seizure and coma; others include tremors, paresthesias, headache, mental status changes, and changes in motor and sensory functions [see Adverse Reactions (6.1, 6.2)].
Are Prograf capsules and Prograf granules the same as tacrolimus tablets?
PROGRAF capsules and PROGRAF Granules are types of tacrolimus immediate-release drugs and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.